Ozempic (semaglutide) has become one of the most popular treatments for weight loss and type 2 diabetes.
And with its rise, many men are asking: does Ozempic lower testosterone?
The short answer: current research shows Ozempic does not lower testosterone.
In fact, studies show that for many men, especially those with obesity or type 2 diabetes, it may actually help raise testosterone levels.
Still, results aren’t the same for everyone, and some men have reported sexual side effects.
Let’s look at what the science really says.
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How Ozempic (Semaglutide) Works in the Body
Ozempic (semaglutide) is a GLP-1 receptor agonist.
That means it mimics a natural hormone in the body that helps regulate blood sugar, slows digestion, and reduces appetite.
For most people, this leads to significant weight loss and better metabolic health.
Because hormones are tied to body fat and insulin sensitivity, it makes sense that Ozempic could influence testosterone levels in men.
Testosterone, Weight Loss, and Male Hormones: The Connection
Low testosterone is common in men with obesity and type 2 diabetes.
That’s because excess fat increases aromatase activity, an enzyme that converts testosterone into estrogen, while high inflammation and poor insulin sensitivity further disrupt hormone production.
When men lose weight, testosterone usually improves.
That’s why treatments like Ozempic, which support fat loss and metabolic health, are closely linked to better hormone balance.
Ozempic and Testosterone Levels: What the Research Shows
Recent studies give us a clearer picture:
- ENDO 2025 study: Over 18 months, men taking GLP-1 medications like Ozempic saw their rate of normal testosterone rise from 53% to 77%. That’s a strong sign that semaglutide supports hormonal recovery in men with obesity and low T.
- Other clinical studies: Men with diabetes and obesity often see testosterone improve as they lose weight and reduce insulin resistance.
- Reports in non-diabetic men: A few men using Ozempic solely for weight management have reported erectile dysfunction or symptoms of low testosterone, but these cases are rare compared to the overall trend.
Does Ozempic Lower Testosterone or Improve It?
So, does Ozempic lower testosterone? Based on current evidence, the answer is no.
For most men, it either has no negative impact or it actually helps improve testosterone.
The key factor is weight loss and improved metabolic health.
That said, individual responses vary.
Some men report side effects like ED, which may or may not be directly related to testosterone levels.
Why Semaglutide Often Boosts Testosterone in Men
Here are the main ways Ozempic may indirectly improve testosterone:
- Weight loss reduces aromatase activity, which means less testosterone is converted into estrogen.
- Lower inflammation supports better hormonal signaling.
- Improved insulin sensitivity helps restore normal testicular function and testosterone production.
These benefits explain why men with obesity and diabetes are most likely to see meaningful improvements.
Risks and Exceptions: Can Ozempic Affect Testosterone Negatively?
While the majority of studies point toward improved testosterone levels, there are some exceptions:
- A small number of men have reported erectile dysfunction after starting Ozempic.
- Men who are not obese or diabetic may not see the same hormonal benefits.
- Animal studies have shown mixed effects, but human data is more supportive of testosterone improvements.
Because of these mixed results, regular monitoring is the safest approach.
Who Benefits Most from Ozempic’s Hormonal Effects?
Here who can benefit the most from Ozempic’s hormonal effects:
- Men with obesity and type 2 diabetes: Most likely to see testosterone levels improve.
- Men using Ozempic for weight loss only: Many still see improvements, but a few may notice side effects.
- Non-diabetic, lean men: Little evidence of hormonal benefit; Ozempic isn’t typically prescribed in these cases.
What Men Should Do If They’re Concerned About Low-T
If you’re starting Ozempic, or already on it, it’s smart to check your testosterone levels before treatment and monitor them over time.
If symptoms of low testosterone continue, treatments like TRT (testosterone replacement therapy) may help.
At Rewind Anti-Aging, we focus on balancing hormones and optimizing health.
Our programs include testosterone therapy, peptide treatments, and advanced weight loss options like semaglutide, so men get support in every area of health.
How Rewind Anti-Aging Helps with Testosterone and Weight Loss
We don’t just focus on one solution, we look at the whole picture.
For men concerned about low testosterone while using Ozempic, we offer customized plans that may include TRT, hormone optimization, and medical weight loss programs.
The goal is to help you look, feel, and perform at your best.
Conclusion: Does Semaglutide Affect Testosterone Levels?
So, does Ozempic lower testosterone?
The evidence says no.
For most men, Ozempic either supports normal testosterone levels or helps raise them by improving weight and metabolism.
Still, every man responds differently, and monitoring hormone health is essential.
If you’re concerned about testosterone or looking for personalized solutions, Rewind Anti-Aging can help you find the right balance for long-term health and performance.
FAQs: Does Ozempic Lower Testosterone
What hormone does Ozempic suppress?
Ozempic mimics the hormone GLP-1, which helps control blood sugar and appetite. It doesn’t suppress testosterone or other male hormones directly.
Can Ozempic mess up my hormones?
There’s no evidence that Ozempic disrupts hormone balance in men. In fact, many studies show it can improve testosterone by supporting weight loss and better metabolism.
What does Ozempic do for men?
For men, Ozempic helps regulate blood sugar, reduces appetite, and supports weight loss. These changes often lead to improvements in testosterone, energy, and overall health.
Do men lose muscle on Ozempic?
Some men may lose muscle if they drop weight too quickly without enough protein or resistance training. Combining Ozempic with exercise and proper nutrition helps preserve muscle mass.
Does Ozempic raise or lower testosterone?
Research suggests Ozempic doesn’t lower testosterone. For many men—especially those with obesity or type 2 diabetes—it may actually raise testosterone levels.
Is semaglutide the same as Ozempic?
Yes. Semaglutide is the generic name, and Ozempic is the brand name. Other brands like Wegovy also contain semaglutide, but they’re approved for slightly different uses.
Brian Burk is the CEO and founder of Rewind Anti-Aging of Miami. Inspired by his own health transformation through hormone therapy, he launched Rewind to help others restore their energy, hormones, and vitality. With a background in engineering and consulting, Brian now leads a dedicated team committed to helping clients ‘rewind’ the clock on their health.
