NAD+ IV Therapy & Injections

NAD+ stands for nicotinamide adenine dinucleotide. It is a coenzyme found in every living cell in your body. The '+' sign refers to its oxidized form, which is the active form that participates in metabolic reactions. NAD+ is essential for converting food into cellular energy (ATP), activating DNA repair enzymes (sirtuins and PARPs), regulating circadian rhythm, and maintaining cellular communication. Without NAD+, your cells cannot function — it is literally required for life.

NAD+ levels decline due to a combination of factors: increased activity of CD38, an enzyme that consumes NAD+ as part of the immune and inflammatory response; increased demand for DNA repair as accumulated cellular damage rises with age; decreased production of NAD+ precursors; and chronic inflammation, which accelerates NAD+ consumption. In human skin, adults aged 51 to 70 averaged less than half the NAD+ of adults aged 30 to 50, and NAD+ also falls with age in the brain and in muscle. This decline is increasingly recognized as a driver of — not just a consequence of — the aging process.

NAD+ IV infusions typically take 2 to 4 hours depending on the dose. The infusion must be administered slowly because rapid infusion commonly causes uncomfortable side effects — particularly chest tightness, nausea, and cramping. Our clinical team adjusts the drip rate throughout the session to ensure comfort. Most patients read, work on their laptop, or relax during the infusion. We offer a comfortable clinical environment designed for extended IV therapy sessions.

Most patients begin with a loading phase of 3 to 5 sessions over one to two weeks to rapidly replenish depleted NAD+ stores. After the loading phase, maintenance infusions are typically scheduled once monthly to sustain optimal levels. Some patients, particularly those using NAD+ for addiction support or intensive anti-aging protocols, may benefit from more frequent sessions initially. Your provider will design a protocol based on your goals, baseline health, and response to treatment.

During the infusion, some patients experience a warm sensation in the chest, mild nausea, or abdominal cramping — these are common reactions to NAD+ and are managed by slowing the infusion rate. Most patients tolerate the infusion well once the drip rate is optimized. After the infusion, the most commonly reported experiences are increased mental clarity, improved energy, and a sense of overall well-being. Many patients describe feeling 'switched on' or 'clear-headed' in the hours and days following treatment. The benefits tend to be cumulative over multiple sessions.

Oral NAD+ precursors — such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) — are available as supplements and raise NAD+ in human trials: in one six-week trial, 1,000 mg of NR a day raised NAD+ in blood cells by about 60%. The body converts these precursors into NAD+. IV NAD+ delivers the coenzyme directly into the bloodstream, and an NAD+ injection delivers it under the skin; both bypass the digestive system. Your provider will recommend the route that fits your goals and schedule.

NAD+ injections deliver nicotinamide adenine dinucleotide under the skin (subcutaneously) instead of through an IV. At Rewind, NAD+ injections come as a 10 mL vial of 200 mg/mL NAD+ that you inject yourself at home, on the dose and schedule your provider sets — no 2-to-4-hour clinic infusion for each dose.

The most common are redness, swelling, or tenderness where you inject, and flushing, nausea, or lightheadedness if the dose goes in too quickly. Headache and fatigue are also reported. Rotating injection sites helps with local soreness.